GRM2 and SLC38A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GRM2	SLC38A1
Description		glutamate metabotropic receptor 2	solute carrier family 38 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Axon Neuronal Cell Body Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Amino Acid:sodium Symporter Activity Neutral Amino Acid:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Behavioral Response To Nicotine Response To Cocaine Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis Regulation Of Response To Drug	Neurotransmitter Uptake Amino Acid Transmembrane Transport Sodium Ion Transport Amino Acid Transport Glutamine Transport Female Pregnancy Neutral Amino Acid Transport L-amino Acid Transport Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Astrocytic Glutamate-Glutamine Uptake And Metabolism Amino acid transport across the plasma membrane
Drugs		LY2140023	Asparagine
Diseases
GWAS			Birth weight ( 31043758) Gout ( 32238385) Morning person ( 30696823) Offspring birth weight ( 31043758) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	30 interacting genes: AMIGO1 AQP6 BMP10 C1QL4 CD79A CREB3 FATE1 FFAR2 GPR152 GPR42 GRM2 IGFBP5 IL1RL1 PDCD1LG2 PGRMC2 PMP22 PTPN11 RPRM SCGB1D1 SCN3B SERP2 SLC10A1 SLC10A6 SLC13A4 SMIM3 SSMEM1 STRIT1 TMEM60 TMPPE TRARG1
Entrez ID		2912	81539
HPRD ID		04977	12245
Ensembl ID		ENSG00000164082	ENSG00000111371
Uniprot IDs		Q14416	A0A024R124 F8VX04 Q9H2H9
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
Enriched GO Terms of Interacting Partners?
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