MRPL18 and LAPTM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MRPL18	LAPTM5
Description		mitochondrial ribosomal protein L18	lysosomal protein transmembrane 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit	Lysosome Lysosomal Membrane Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Binding Protein Sequestering Activity
	Biological Process	Translation RRNA Import Into Mitochondrion	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of MAPK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Golgi To Lysosome Transport Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS			Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: LAPTM5 YIF1A	39 interacting genes: AIG1 ANKRD13A C4orf3 CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1
Entrez ID		29074	7805
HPRD ID		14744	03280
Ensembl ID		ENSG00000112110	ENSG00000162511
Uniprot IDs		Q9H0U6	Q13571 Q5TBB8
PDB IDs		3J7Y 5OOL 5OOM 6NU2 6NU3 6ZM5 6ZM6 7A5F 7A5G
Enriched GO Terms of Interacting Partners?
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