GRIK1 and CYSLTR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		GRIK1	CYSLTR2
Description		glutamate ionotropic receptor kainate type subunit 1	cysteinyl leukotriene receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Membrane	Cellular_component Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Cysteinyl Leukotriene Receptor Activity Leukotriene Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential	Immune Response Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Leukotriene Signaling Pathway Cellular Response To Glucagon Stimulus
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Glucagon signaling in metabolic regulation Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production LTC4-CYSLTR mediated IL4 production
Drugs		Glutamic acid Butabarbital Topiramate Tezampanel	Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		9 interacting genes: CYSLTR2 DLG4 FLNA GRIP1 HOMER1 IFNGR2 PICK1 SDCBP TAAR1	19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE
Entrez ID		2897	57105
HPRD ID		00693	09293
Ensembl ID		ENSG00000171189	ENSG00000152207
Uniprot IDs		B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086	A4ZKH2 Q5KU17 Q9NS75
PDB IDs		2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?
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