GRB2 and B2M

Number of citations of the paper that reports this interaction (PubMedID 18624398)
18

Data Source:
BioGRID (two hybrid)

		GRB2	B2M
Description		growth factor receptor bound protein 2	beta-2-microglobulin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Vesicle Membrane Extracellular Exosome Grb2-EGFR Complex	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Endosome Lumen Specific Granule Lumen MHC Class I Protein Complex MHC Class II Protein Complex MHC Class I Peptide Loading Complex Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Lumen HFE-transferrin Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding Ephrin Receptor Binding	Protein Binding MHC Class II Protein Complex Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Aging Insulin Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Receptor Internalization Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Retina Homeostasis Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Cytokine Production Iron Ion Transport Immune Response Learning Or Memory Response To Xenobiotic Stimulus Negative Regulation Of Neuron Projection Development Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Protein Binding T Cell Differentiation In Thymus Regulation Of Iron Ion Transport Protein Refolding Regulation Of Erythrocyte Differentiation Response To Cadmium Ion Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Positive Regulation Of T Cell Activation Protein Homotetramerization Iron Ion Homeostasis Cellular Response To Iron Ion Cellular Response To Iron(III) Ion Cellular Response To Nicotine Modulation Of Age-related Behavioral Decline Negative Regulation Of Receptor Binding Positive Regulation Of Receptor Binding Positive Regulation Of Ferrous Iron Binding Positive Regulation Of Transferrin Receptor Binding Amyloid Fibril Formation Positive Regulation Of Cellular Senescence Negative Regulation Of Forebrain Neuron Differentiation
Pathways		Interleukin-15 signaling Interleukin-15 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Signaling by ALK fusions and activated point mutants	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Pegademase 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid	3-Indolebutyric Acid N-Formylmethionine Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Deep white matter hyperintensities ( 32517579) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 29848360 26502338 28714469) Systemic sclerosis ( 31672989) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		400 interacting genes: A2M ABI3 ABI3BP ABL1 ABL2 ACAP1 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AGR2 AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANKRD13A ANKRD23 ANXA2 AP4S1 APCS APOH APP AR ARHGAP17 ARHGAP32 ARHGAP35 ARID5A ASAP1 ASAP2 AUNIP AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM BTG1 C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCDC28B CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CFH CHRM4 CHRND CKS2 CLNK CLU COPB1 COX6A1 CPSF7 CRBN CRK CRKL CSF1R CSF3R CSN2 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDIT4L DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 DTX3 DVL2 E2F2 ECHS1 EFHC2 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESD ESR1 ETV6 FABP1 FASLG FCGR2A FCGR2B FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GAREM1 GC GGN GHR GIT1 GPANK1 GRAP2 GRB7 GSTK1 H1-0 HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HSPA5 HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA0408 KIAA1549L KIF3A KIT KPNA2 KPRP KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LNX2 LY6G6F LZTS2 MAP1A MAP2 MAP4K1 MAP4K3 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MAPT MED19 MED28 MEI4 MERTK MET METTL27 MIA2 MICAL1 MLXIPL MS4A2 MSI2 MST1R MT-ATP8 MT-ND4 MTA1 MTA3 MUC1 MYG1 MYH11 MYH9 MYO18A MYOZ1 NADK NAP1L5 NCKIPSD NCL NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL OLIG1 PACRGL PAG1 PAK1 PAK2 PAK4 PBXIP1 PCDHB5 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PHETA1 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLEKHA7 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRR5-ARHGAP8 PRRC2A PRRG4 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RNF208 RPS6KA1 SELL SF3A2 SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPATA2L SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TBC1D3B TBC1D3G TCEAL8 TCERG1 TEK TF TFG TLE5 TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIB3 TRIM27 TSC2 TSPAN2 TUB TXK TYRO3 UBA1 UBA52 UBC UQCC2 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM VPS37C WAS WASF1 WASF2 WASL WBP11 WDFY3 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB12 ZBTB7B ZMAT1 ZNF341 ZNF474 ZNF620	23 interacting genes: A2M BAG6 CALR CD1A CD1B CD1D CD1E CD8A CHRM4 CRYAB CXCR4 FCGRT GRB2 HFE HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HSPB2 LILRB1 PRSS23
Entrez ID		2885	567
HPRD ID		00150	00189
Ensembl ID		ENSG00000177885	ENSG00000166710
Uniprot IDs		B0LPF3 P62993	P61769
PDB IDs		1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z 5CDW 6ICG 6ICH 6SDF 6VK2 6WM1 6WO2	1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3W39 3WL9 3WLB 3WUW 3X11 3X12 3X13 3X14 4E0K 4E0L 4E5X 4EN3 4EUP 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K71 4K7F 4KDT 4L29 4L3C 4L3E 4L4T 4L4V 4LCW 4LCY 4LHU 4LNR 4M8V 4MJ5 4MJ6 4MJI 4MNQ 4N0F 4N0U 4N8V 4NNX 4NNY 4NO0 4NO2 4NO3 4NO5 4NQC 4NQD 4NQE 4NQV 4NQX 4NT6 4O2C 4O2E 4O2F 4ONO 4PJ5 4PJ7 4PJ8 4PJ9 4PJA 4PJB 4PJC 4PJD 4PJE 4PJF 4PJG 4PJH 4PJI 4PJX 4PR5 4PRA 4PRB 4PRD 4PRE 4PRH 4PRI 4PRN 4PRP 4QOK 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4R9H 4RA3 4RAH 4RMQ 4RMR 4RMS 4RMT 4RMU 4RMV 4RMW 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4U6X 4U6Y 4UQ2 4UQ3 4WC8 4WDI 4WJ5 4WO4 4WU5 4WU7 4WUU 4WW2 4WWK 4X0S 4X6C 4X6D 4X6E 4X6F 4XXC 4Z76 4Z77 4Z78 5B38 5B39 5BJT 5BRZ 5BS0 5BXF 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0I 5C0J 5C9J 5CFH 5CKA 5CKG 5CS7 5CSB 5CSG 5D2L 5D2N 5D5M 5D7I 5D7J 5D7L 5D9S 5DDH 5DEF 5DEG 5E00 5E6I 5E9D 5ENW 5EO0 5EO1 5EOT 5EU3 5EU4 5EU5 5EU6 5EUO 5F1I 5F7D 5F9J 5FA3 5FA4 5FDW 5GR7 5GRD 5GRG 5GSB 5GSD 5GSR 5GSV 5GSX 5HGA 5HGB 5HGD 5HGH 5HHM 5HHN 5HHO 5HHP 5HHQ 5HYJ 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5IRO 5ISZ 5IUE 5J1A 5JHD 5JZI 5KNM 5L2J 5L2K 5MEN 5MEO 5MEP 5MEQ 5MER 5N1Y 5N6B 5NHT 5NME 5NMF 5NMG 5NMH 5NMK 5NQ1 5NQ3 5NQK 5OPI 5SWQ 5T6W 5T6X 5T6Y 5T6Z 5T70 5TEZ 5TRZ 5TS1 5TXS 5U16 5U17 5U1R 5U2V 5U6Q 5U72 5U98 5V5L 5V5M 5VGD 5VGE 5VUD 5VUE 5VUF 5VVP 5VWD 5VWF 5VWH 5VWJ 5VZ5 5W1V 5W1W 5W67 5W69 5W6A 5WER 5WHK 5WJL 5WJN 5WKE 5WKF 5WKG 5WKH 5WKI 5WL1 5WMN 5WMO 5WMP 5WMQ 5WMR 5WSH 5WWI 5WWJ 5WWU 5WXC 5WXD 5XOS 5XOT 5XOV 5YXN 5YXU 6AEE 6AM5 6AMT 6AMU 6APN 6AT5 6AT9 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6C09 6C15 6C97 6C98 6C99 6CUG 6D29 6D2B 6D2R 6D2T 6D64 6D78 6DKP 6EI2 6ENY 6EQA 6EQB 6EWA 6EWC 6EWO 6FGB 6G3J 6G3K 6GGM 6GH1 6GH4 6GHN 6GK3 6GL1 6ID4 6IEX 6ILM 6J1V 6J1W 6J29 6J2A 6J2E 6J2G 6J2H 6J2I 6J2J 6JOZ 6JP3 6JTN 6JTO 6JTP 6K60 6K7T 6LA6 6LA7 6M1B 6M24 6M2J 6M2K 6MPP 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6MWR 6NCA 6NHA 6NPR 6NUX 6O4Y 6O4Z 6O51 6O53 6O9B 6O9C 6OPD 6P23 6P27 6P2C 6P2F 6P2S 6P64 6PA1 6PAG 6PBH 6PTB 6PTE 6PUC 6PUD 6PUE 6PUF 6PUG 6PUH 6PUI 6PUJ 6PUK 6PUL 6PUM 6PVC 6PVD 6PYJ 6PYL 6PYV 6PYW 6PZ5 6Q3K 6Q3S 6QIO 6QIP 6R2L 6RP9 6RPA 6RPB 6RSY 6SS7 6SS8 6SS9 6SSA 6TDO 6TDP 6TDQ 6TDR 6TDS 6TMO 6TRN 6TRO 6UJO 6UJQ 6UK2 6UK4 6ULI 6ULK 6ULN 6ULR 6UON 6UZ1 6UZM 6UZN 6UZO 6UZP 6UZQ 6UZS 6V2O 6V2P 6V2Q 6V3J 6V7Y 6V7Z 6V80 6VB0 6VB1 6VB2 6VB3 6VB4 6VB5 6VB6 6VB7 6VIU 6VM7 6VM8 6VM9 6VMA 6VMC 6VMX 6VPZ 6VQ2 6VQD 6VQE 6VQO 6VQY 6VQZ 6VR1 6VR5 6VRM 6VRN 6W9U 6W9V 6WZY 6X00 6XQP 6Y26 6Y27 6Y28 6Y29 6Y2A 6Y2B 7AFV 7C9V 7K80 7K81 7KGO 7KGP 7KGQ 7KGR 7KGS 7KGT 7LFZ 7LG0 7LG2 7LG3
Enriched GO Terms of Interacting Partners?
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