GPX4 and MATK

		GPX4	MATK
Description		glutathione peroxidase 4	megakaryocyte-associated tyrosine kinase
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome	Cytosol Membrane
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Chromatin Organization Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Spermatogenesis Aging Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Long-chain Fatty Acid Biosynthetic Process Regulation Of Inflammatory Response Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives	Downregulation of ERBB2 signaling
Drugs		Glutathione Glutathione Glutathione disulfide	Fostamatinib
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)	Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: APBA3 EGR4 FUT5 GAMT GTF2F1 MAPK13 MATK PARK7 PRDX6 ZNF197	26 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 GPX4 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NFIX NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		2879	4145
HPRD ID		11819	02496
Ensembl ID		ENSG00000167468	ENSG00000007264
Uniprot IDs		P36969 Q6PI42	F1T0G6 P42679
PDB IDs		2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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