TRIM59 and UBE2J2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TRIM59	UBE2J2
Description		tripartite motif containing 59	ubiquitin conjugating enzyme E2 J2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell	Protein Polyubiquitination Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		28 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM OTOL1 PIN1 PLLP PPM1L RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MDM2 MGRN1 NEDD4L PRKN PUSL1 RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		286827	118424
HPRD ID		15568	15600
Ensembl ID		ENSG00000213186	ENSG00000160087
Uniprot IDs		Q8IWR1	A0A024R075 A6NGS0 Q8N2K1
PDB IDs			2F4W
Enriched GO Terms of Interacting Partners?
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