ANG and TNFSF8

Number of citations of the paper that reports this interaction (PubMedID 11751393)
14

Data Source:
HPRD (in vitro)

		ANG	TNFSF8
Description		angiogenin	TNF superfamily member 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytosol Actin Cytoskeleton Growth Cone Cytoplasmic Vesicle Angiogenin-PRI Complex Neuronal Cell Body	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	DNA Binding Actin Binding Endonuclease Activity Endoribonuclease Activity Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding Protein Homodimerization Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone TRNA Catabolic Process Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Signal Transduction Cell-cell Signaling Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium
Pathways		Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 28240269)	Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 30500874 21102463 23266558) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)
Interacting Genes		8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8	4 interacting genes: ANG BMP10 CXCL9 TNFRSF8
Entrez ID		283	944
HPRD ID		00105	04852
Ensembl ID		ENSG00000214274	ENSG00000106952
Uniprot IDs		P03950 W0UV28	A0A087X228 P32971 Q52M88
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V
Enriched GO Terms of Interacting Partners?
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