GMDS and KCNAB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GMDS	KCNAB3
Description		GDP-mannose 4,6-dehydratase	potassium voltage-gated channel subfamily A regulatory beta subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Protein Binding GDP-mannose 4,6-dehydratase Activity Identical Protein Binding NADP+ Binding	Aldo-keto Reductase (NADP) Activity Voltage-gated Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Notch Signaling Pathway GDP-mannose Metabolic Process 'de Novo' GDP-L-fucose Biosynthetic Process	Potassium Ion Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport
Pathways		GDP-fucose biosynthesis	Voltage gated Potassium channels
Drugs		Guanosine-5'-Diphosphate-Rhamnose Guanosine-5'-Diphosphate
Diseases
GWAS		Anthropometric traits (multi-trait analysis) ( 30166351) Caudate nucleus volume ( 21502949) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Fasting glucose ( 34074324) Fish intake frequency ( 31320941) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (low intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Haemorrhoidal disease ( 33888516) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Impulsivity (non-planning) ( 30718321) Intraocular pressure ( 29617998 29785010 31959993 30054594) Iris heterochromicity ( 30895295) Late-onset myasthenia gravis ( 26562150) Medication use (diuretics) ( 31015401) Monobrow ( 27182965) Monobrow thickness ( 26926045) Myocardial infarction ( 33532862) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Orofacial clefts ( 33137956) Pulse pressure ( 30578418) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Sub-cortical grey matter volume ( 31530798) Urate levels ( 31578528) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Refractive error ( 32231278) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		2 interacting genes: KCNAB3 NTAQ1	5 interacting genes: APP GMDS NEDD4L PLEKHF2 ZBTB14
Entrez ID		2762	9196
HPRD ID		11925	04983
Ensembl ID		ENSG00000112699	ENSG00000170049
Uniprot IDs		O60547	O43448
PDB IDs		1T2A 5IN4 5IN5 6GPJ 6GPK 6GPL 6Q94
Enriched GO Terms of Interacting Partners?
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