TMEM97 and ORC1

		TMEM97	ORC1
Description		transmembrane protein 97	origin recognition complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Rough Endoplasmic Reticulum Membrane Nuclear Membrane	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Cholesterol Homeostasis	DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		70 interacting genes: ADCYAP1R1 APP AQP12B AQP2 AQP6 ARL13B ASZ1 ATP6AP2 BCL2L13 BIK CD53 CD74 CGRRF1 CLDN7 CLSTN3 CPLX4 CRLF3 EBP ERAL1 ERGIC3 FAM209A FFAR2 FKBP7 FRMD3 FXYD3 GJB3 GJB5 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LEUTX LHFPL5 LIME1 LRRC59 MFF MRM1 MTIF3 MUC1 NDUFAF1 NDUFAF2 NEMP1 ORC1 PDCD1LG2 PDZK1IP1 PLP1 POLDIP2 PSCA REEP1 RHCG RNF167 RNF170 SAR1A SGPL1 SLC14A1 SLC14A2 SPINT1 SSMEM1 TADA1 TBC1D29P TMEM106C TMEM14B TMEM45B TMEM52B TMEM79 TMX2 UTP4 VSIR	25 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 TMEM97 XPO1
Entrez ID		27346	4998
HPRD ID		14343	03544
Ensembl ID		ENSG00000109084	ENSG00000085840
Uniprot IDs		Q5BJF2	B7Z8H0 Q13415 Q96F82
PDB IDs			5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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