KLHL20 and RECK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KLHL20	RECK
Description		kelch like family member 20	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		42 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 BRINP2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20	44 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL RPS6KA1 SIGMAR1 SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		27252	8434
HPRD ID		13918	05567
Ensembl ID		ENSG00000076321	ENSG00000122707
Uniprot IDs		Q9Y2M5	A8K9D8 O95980 Q6P9E2
PDB IDs		5YQ4 6GY5
Enriched GO Terms of Interacting Partners?
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