SLC39A1 and HTR2C

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SLC39A1	HTR2C
Description		solute carrier family 39 member 1	5-hydroxytryptamine receptor 2C
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Signaling Receptor Binding Zinc Ion Transmembrane Transporter Activity Protein Binding Inorganic Cation Transmembrane Transporter Activity	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	In Utero Embryonic Development Cation Transport Embryonic Cranial Skeleton Morphogenesis Limb Development Zinc Ion Transmembrane Transport	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Zinc influx into cells by the SLC39 gene family	Serotonin receptors G alpha (q) signalling events
Drugs			Tramadol Ziprasidone Methysergide Cabergoline Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Epicept NP-1 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS		Age at first birth ( 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Lentiform nucleus volume ( 22903471) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: CERS2 COMT CXCL16 CXCL9 CYB561 HTR2C HTR4 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2 TRARG1 YIPF6	34 interacting genes: APBA1 ARRB2 ATP2B3 ATP6AP2 ATP6V0C C4orf3 CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MFSD14A MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1
Entrez ID		27173	3358
HPRD ID		11984	02429
Ensembl ID		ENSG00000143570	ENSG00000147246
Uniprot IDs		A0A0A0MTL8 Q9NY26	K9J958 P28335
PDB IDs			6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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