TJP3 and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 10601346)
323

Data Source:
HPRD (in vitro, in vivo)

		TJP3	CLDN1
Description		tight junction protein 3	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Bicellular Tight Junction Cell Junction	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Tight Junction
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Cell Adhesion Aging Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Hyperosmotic Salinity Response Cell-cell Junction Organization Response To Ethanol Viral Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		5 interacting genes: CLDN1 FASLG GJC1 PATJ TJP1	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		27134	9076
HPRD ID		18194	04760
Ensembl ID		ENSG00000105289	ENSG00000163347
Uniprot IDs		O95049	A5JSJ9 O95832
PDB IDs		3KFV
Enriched GO Terms of Interacting Partners?
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