GJB2 and NGLY1

		GJB2	NGLY1
Description		gap junction protein beta 2	N-glycanase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Connexin Complex Lateral Plasma Membrane Cell Body Perinuclear Region Of Cytoplasm Astrocyte Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Response To Ischemia Cell-cell Signaling Aging Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Response To Antibiotic Decidualization Inner Ear Development Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Epididymis Development Gap Junction-mediated Intercellular Transport	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E NGLY1 PEX12 PLEKHB2 SAR1A SHISAL1 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR	25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		2706	55768
HPRD ID		00413	10118
Ensembl ID		ENSG00000165474	ENSG00000151092
Uniprot IDs		H9U1J4 P29033	Q96IV0
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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