GJB1 and BMP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GJB1	BMP10
Description		gap junction protein beta 1	bone morphogenetic protein 10
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane Lateral Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding
	Biological Process	Cell-cell Signaling Nervous System Development Purine Ribonucleotide Transport Gap Junction Assembly Transmembrane Transport Epididymis Development	Kidney Development Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly	Signaling by BMP Molecules associated with elastic fibres
Drugs
Diseases
GWAS			Chronic rhinosinusitis ( 33393196)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	65 interacting genes: ACVR2A ACVR2B AP4B1 APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND C2orf42 CCDC70 CD33 CISD2 CLDN7 CNRIP1 COQ9 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 PNO1 RCN1 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35C2 SLC38A1 SLC4A1 SNRNP27 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR
Entrez ID		2705	27302
HPRD ID		02367	09788
Ensembl ID		ENSG00000169562	ENSG00000163217
Uniprot IDs		A0A654ICJ7 P08034	O95393
PDB IDs		1TXH 5KK9	6SF1 6SF3
Enriched GO Terms of Interacting Partners?
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