TPK1 and OPLAH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

		TPK1	OPLAH
Description		thiamin pyrophosphokinase 1	5-oxoprolinase, ATP-hydrolysing
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Thiamine Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Thiamine Binding Identical Protein Binding	Protein Binding ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding
	Biological Process	Thiamine Metabolic Process Thiamine Diphosphate Biosynthetic Process Phosphorylation	Glutathione Metabolic Process
Pathways		Vitamin B1 (thiamin) metabolism	Glutathione synthesis and recycling Defective OPLAH causes OPLAHD
Drugs		Thiamine Pyrithiamine Pyrophosphate	Glutamic acid
Diseases
GWAS		Fruit consumption ( 32066663) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Iris color (b* coordinate) ( 30895295) Smoking status (heavy vs never) ( 26423011)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748 23093944)
Interacting Genes		1 interacting genes: OPLAH	5 interacting genes: GK HOXA1 POU6F2 TPK1 ZNF451
Entrez ID		27010	26873
HPRD ID		06967	14880
Ensembl ID		ENSG00000196511	ENSG00000178814
Uniprot IDs		A0A090N8Y0 F5GZG6 Q9H3S4	O14841
PDB IDs		1OLY 3S4Y
Enriched GO Terms of Interacting Partners?
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