LRIG1 and MICOS10-NBL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LRIG1	MICOS10-NBL1
Description		leucine rich repeats and immunoglobulin like domains 1	MICOS10-NBL1 readthrough
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix	Extracellular Space
	Molecular Function	Protein Binding	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Sensory Perception Of Sound Hair Cycle Process Otolith Morphogenesis Innervation	Signal Transduction Nervous System Development Animal Organ Morphogenesis Negative Regulation Of BMP Signaling Pathway Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis
Pathways		Signaling by EGFR Negative regulation of MET activity
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Antibody status in Tripanosoma cruzi seropositivity ( 24324551) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Blood urea nitrogen levels ( 29403010) Carotid intima media thickness ( 21909108) Chronic kidney disease ( 29124443) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29124443) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 29124443) Hyperuricemia ( 29124443) Intraocular pressure ( 30054594) Iron status biomarkers (iron levels) ( 33536631) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Non-glioblastoma glioma ( 28346443) Orofacial clefts ( 33137956) Pulse pressure ( 27841878) QRS duration ( 27577874 21076409 27659466) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Retinal detachment or retinal break ( 31816047) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27841878) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		5 interacting genes: CBL GLRX3 MICOS10-NBL1 NBL1 ZBTB16	11 interacting genes: DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD PLA2G2F SLPI UBQLN1 UBQLN2
Entrez ID		26018	100532736
HPRD ID		10057
Ensembl ID		ENSG00000144749	ENSG00000158747
Uniprot IDs		Q96JA1	P41271
PDB IDs		4U7L 4U7M	4X1J 4YU8
Enriched GO Terms of Interacting Partners?
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