L3MBTL1 and H1-5

Number of citations of the paper that reports this interaction (PubMedID 17540172)
172

Data Source:
HPRD (in vivo, in vitro)

		L3MBTL1	H1-5
Description		L3MBTL histone methyl-lysine binding protein 1	H1.5 linker histone, cluster member
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane	Chromatin Nucleosome Heterochromatin Nucleus
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Chromatin Organization Regulation Of Mitotic Nuclear Division Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin
Pathways		Regulation of TP53 Activity through Methylation	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)
Interacting Genes		9 interacting genes: CBX3 ETV6 ETV7 FXR2 H1-5 H4-16 RB1 SETD7 SLC12A5	31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		26013	3009
HPRD ID		16387	00821
Ensembl ID		ENSG00000185513	ENSG00000184357
Uniprot IDs		Q9Y468	P16401
PDB IDs		1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB	2FE2 2RHI
Enriched GO Terms of Interacting Partners?
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