SYF2 and MCM3

Number of citations of the paper that reports this interaction (PubMedID 16951160)
4

Data Source:
BioGRID (pull down, pull down)

		SYF2	MCM3
Description		SYF2 pre-mRNA splicing factor	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	RNA Binding Protein Binding	DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	MRNA Splicing, Via Spliceosome In Utero Embryonic Development Mitotic G2 DNA Damage Checkpoint Signaling Gastrulation Positive Regulation Of Cell Population Proliferation Embryonic Organ Development	Double-strand Break Repair Via Break-induced Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways		mRNA Splicing - Major Pathway	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Glycated hemoglobin levels ( 34059833 28898252) Lead levels ( 26025379) Male-pattern baldness ( 29146897 27182965) Mean corpuscular volume ( 27863252) Plateletcrit ( 27863252) Urate levels in obese individuals ( 25811787)	Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		5 interacting genes: APP ARMC7 CCNDBP1 MCM3 MLH1	37 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TFAP2B TRIM28 YWHAQ
Entrez ID		25949	4172
HPRD ID		07386	04072
Ensembl ID		ENSG00000117614	ENSG00000112118
Uniprot IDs		O95926	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs		5MQF 5XJC 5YZG 6ICZ 6ID0 6ID1 6QDV 7A5P	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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