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SIN3A and MECP2
Number of citations of the paper that reports this interaction (PubMedID
11441023
)
68
Data Source:
HPRD
(in vivo)
SIN3A
MECP2
Description
SIN3 transcription regulator family member A
methyl-CpG binding protein 2
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Heterochromatin
Extracellular Space
Nucleus
Nucleoplasm
Centrosome
Cytosol
Postsynapse
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
RNA Binding
MRNA Binding
Protein Binding
Methyl-CpG Binding
Double-stranded Methylated DNA Binding
Protein Domain Specific Binding
SiRNA Binding
Protein N-terminus Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Behavioral Fear Response
Response To Hypoxia
Startle Response
Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Respiratory Gaseous Exchange By Nervous System Process
Inositol Metabolic Process
Regulation Of Gene Expression By Genetic Imprinting
Glutamine Metabolic Process
Cellular Biogenic Amine Metabolic Process
Mitotic Spindle Organization
Synapse Assembly
Respiratory Gaseous Exchange By Respiratory System
Long-term Memory
Protein Localization
Glucocorticoid Metabolic Process
Positive Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Visual Learning
Post-embryonic Development
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Dendrite Development
Negative Regulation Of Angiogenesis
Histone Methylation
Histone Acetylation
Proprioception
Sensory Perception Of Pain
Cerebellum Development
Ventricular System Development
Cardiolipin Metabolic Process
Social Behavior
Neuron Maturation
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylcholine Metabolic Process
Negative Regulation Of Smooth Muscle Cell Differentiation
Response To Other Organism
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Histone H3-K9 Trimethylation
Positive Regulation Of DNA Methylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
STAT3 nuclear events downstream of ALK signaling
Cytoprotection by HMOX1
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Caffeine consumption from tea (
33287642
)
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Non-albumin protein levels (
29403010
)
Red blood cell traits (
23446634
)
Schizophrenia (
24043878
)
Systemic lupus erythematosus (
26663301
26502338
19838195
)
Interacting Genes
100 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
DMRTC1B
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
TSN
ZBTB16
20 interacting genes:
DNMT1
DNMT3L
GTF2B
H3C15
HDAC1
HIPK2
HMGB1
LBR
NCOR1
PRKACA
PRPF40A
PRPF40B
SIN3A
SKI
SMARCA2
SMARCB1
SOX18
SPI1
TBL1X
TBL1XR1
Entrez ID
25942
4204
HPRD ID
09690
02050
Ensembl ID
ENSG00000169375
ENSG00000169057
Uniprot IDs
Q96ST3
A0A140VKC4
D3YJ43
P51608
Q59FJ6
PDB IDs
1PO4
1QK9
3C2I
5BT2
6C1Y
6OGJ
6OGK
Enriched GO Terms of Interacting Partners
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