GALT and TNK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		GALT	TNK2
Description		galactose-1-phosphate uridylyltransferase	tyrosine kinase non receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium
	Molecular Function	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding	Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	UDP-glucose Metabolic Process Galactose Metabolic Process UDP-glucose Catabolic Process Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Differentiation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Defective GALT can cause Galactosemia Galactose catabolism
Drugs			ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS			Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		9 interacting genes: CCL19 CCL21 GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 UBTD2 VAC14	49 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		2592	10188
HPRD ID		06106	06104
Ensembl ID		ENSG00000213930	ENSG00000061938
Uniprot IDs		A0A0S2Z3Y7 B2RAT6 P07902	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912
PDB IDs		1R3A 5IN3 6GQD	1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM
Enriched GO Terms of Interacting Partners?
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