AMBP and A2M

Number of citations of the paper that reports this interaction (PubMedID 7519849)
8

Data Source:
HPRD (in vivo, in vitro)

		AMBP	A2M
Description		alpha-1-microglobulin/bikunin precursor	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Calcium Channel Inhibitor Activity IgA Binding Heme Binding Protein Homodimerization Activity Calcium Oxalate Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Cell Adhesion Female Pregnancy Negative Regulation Of Endopeptidase Activity Protein-chromophore Linkage Protein Catabolic Process Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response	Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Endopeptidase Activity Stem Cell Differentiation
Pathways		Scavenging of heme from plasma	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 29875488)	Refractive error ( 32231278)
Interacting Genes		13 interacting genes: A2M ALB COX8A DAAM1 ENO1 EXOSC2 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3	98 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		259	2
HPRD ID		01467	00072
Ensembl ID		ENSG00000106927	ENSG00000175899
Uniprot IDs		P02760	P01023
PDB IDs		1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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