SPDEF and COX5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPDEF	COX5A
Description		SAM pointed domain containing ETS transcription factor	cytochrome c oxidase subunit 5A
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex IV
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development	Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport
Pathways			TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)	Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		13 interacting genes: AR CEP57 COX5A ENKD1 ESR1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23	10 interacting genes: COPS6 CYP1A1 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF
Entrez ID		25803	9377
HPRD ID		12176	04799
Ensembl ID		ENSG00000124664	ENSG00000178741
Uniprot IDs		O95238	P20674
PDB IDs		1YO5 2DKX	5Z62
Enriched GO Terms of Interacting Partners?
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