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FYN and EPHA4
Number of citations of the paper that reports this interaction (PubMedID
12084815
)
36
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
FYN
EPHA4
Description
FYN proto-oncogene, Src family tyrosine kinase
EPH receptor A4
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Dendrite
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Cell Surface
Filopodium
Axon
Dendrite
Neuromuscular Junction
Early Endosome Membrane
Neuron Projection
Dendritic Spine
Dendritic Shaft
Perikaryon
Receptor Complex
Axon Terminus
Axonal Growth Cone
Schaffer Collateral - CA1 Synapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
Transmembrane Transporter Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Scaffold Protein Binding
Disordered Domain Specific Binding
Amyloid-beta Binding
Protein Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
PH Domain Binding
Identical Protein Binding
Ephrin Receptor Binding
DH Domain Binding
Protein Tyrosine Kinase Binding
Biological Process
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Heart Process
Protein Phosphorylation
Calcium Ion Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Axon Guidance
Learning
Feeding Behavior
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Hydrogen Peroxide
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Ethanol
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Positive Regulation Of Neuron Death
Negative Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Oxidative Stress-induced Cell Death
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Adult Walking Behavior
Motor Neuron Axon Guidance
Glial Cell Migration
Negative Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Corticospinal Tract Morphogenesis
Negative Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Adherens Junction Organization
Regulation Of GTPase Activity
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Cell Adhesion
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Negative Regulation Of Axon Regeneration
Regulation Of Astrocyte Differentiation
Regulation Of Axonogenesis
Positive Regulation Of Dendrite Morphogenesis
Protein Stabilization
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Nephric Duct Morphogenesis
Cochlea Development
Fasciculation Of Sensory Neuron Axon
Fasciculation Of Motor Neuron Axon
Neuron Projection Guidance
Synapse Pruning
Neuron Projection Fasciculation
Negative Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Response To Amyloid-beta
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
Drugs
Dasatinib
Triglyme
Fostamatinib
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Adolescent idiopathic scoliosis (
26394188
)
Blond vs. brown/black hair color (
30531825
)
Brain imaging (
20100581
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Brown vs. black hair color (
30531825
)
Cortical surface area (MOSTest) (
32665545
)
Diffusing capacity of carbon monoxide (
30694715
)
Diisocyanate-induced asthma (
25918132
)
Entorhinal cortical volume (
31530798
)
Face memory (
31596458
)
Hair color (
29662168
)
Heel bone mineral density (
30598549
)
Immune response to measles-mumps-rubella vaccine (
24811271
)
Nose size (
27182965
)
Paclitaxel-induced neuropathy (
23776197
)
Rostral anterior cingulate cortex volume (
31530798
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels in lean individuals (
25811787
)
Interacting Genes
200 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
ERRFI1
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
HDAC2
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PRRG4
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
18 interacting genes:
ARHGEF15
EFNA1
EFNA3
EFNA4
EFNA5
EFNB2
EFNB3
ERBB2
ETS1
FGFR1
FGFR2
FGFR3
FGFR4
FYN
IKBKG
NGEF
SRC
TNS3
Entrez ID
2534
2043
HPRD ID
00655
03719
Ensembl ID
ENSG00000010810
ENSG00000116106
Uniprot IDs
P06241
A1MA61
P54764
PDB IDs
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
2LW8
2WO1
2WO2
2WO3
3CKH
3GXU
4BK4
4BK5
4BKA
4BKF
4M4P
4M4R
4W4Z
4W50
5JR2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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