ABL1 and MDM2

Number of citations of the paper that reports this interaction (PubMedID 12110584)
59

Data Source:
BioGRID (unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study)
HPRD (in vitro, in vivo)

		ABL1	MDM2
Description		ABL proto-oncogene 1, non-receptor tyrosine kinase	MDM2 proto-oncogene
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Nuclear Body Dendrite Cell Leading Edge Nuclear Membrane Protein-containing Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein-containing Complex Synapse
	Molecular Function	Magnesium Ion Binding Four-way Junction DNA Binding Bubble DNA Binding Phosphotyrosine Residue Binding DNA Binding Transcription Coactivator Activity Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding Kinase Activity SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Neuropilin Binding SH2 Domain Binding Ephrin Receptor Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding Supercoiled DNA Binding Sequence-specific Double-stranded DNA Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Disordered Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Neural Tube Closure B-1 B Cell Homeostasis Positive Regulation Of Protein Phosphorylation B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Protein Phosphorylation Endocytosis Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Regulation Of Axon Extension Regulation Of Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Platelet-derived Growth Factor Receptor-beta Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Endothelial Cell Migration Establishment Of Protein Localization Regulation Of T Cell Differentiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Protein Autophosphorylation Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Mitochondrial Depolarization Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Neuroepithelial Cell Differentiation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade DNA Conformation Change Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Circulatory System Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Actin Filament Branching Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Microtubule Binding Positive Regulation Of Actin Filament Binding Regulation Of Modification Of Synaptic Structure Positive Regulation Of Blood Vessel Branching Activation Of Protein Kinase C Activity Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Iron Ion Positive Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Protein Ubiquitination Protein Sumoylation Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Transcription Factor Catabolic Process Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Cellular Response To Actinomycin D Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress
Pathways		Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity
Drugs		ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid PD-166326 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Fostamatinib Brigatinib Radotinib	Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Lymphocyte counts ( 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494) Response to amphetamines ( 22952603) White blood cell count ( 32888494)	Pneumoconiosis in silica exposure ( 24986923) Red blood cell count ( 32888494)
Interacting Genes		161 interacting genes: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANAPC15 ANKRA2 APBB1 APP AR ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1A CDKN1B CDON CREB1 CRK CRKL CTNND2 DAPK1 DDB1 DDB2 DENND2B DOK1 DOK2 DOK3 DVL2 EMD ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL FBXO7 GJA8 GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HIPK2 HUWE1 INPPL1 JAK1 JAK2 JUN KIT KRT31 LATS2 LRRK1 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PDGFRB PIK3R1 PLCG1 PLEKHA4 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD51B RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHB SHD SHE SLC9A2 SOCS3 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRCIN1 SRPK2 STUB1 TERT TMPO TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	261 interacting genes: ABL1 ABL2 ADRB2 AKAP5 AKT1 ANKRD17 APEX1 APP AR ARRB1 ARRB2 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDC34 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 EGLN3 EID1 EP300 ESR1 EZR F3 FBXO31 FGFR2 FHL2 FKBP1A FOS FOXO1 FOXO3 FOXP3 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KPNA1 LMO7 MAGEA2 MAP1LC3A MAP2 MAPKAPK2 MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NDUFS1 NGFR NOLC1 NOP53 NOTCH1 NPIPB3 NPM1 NR3C1 NUCKS1 NUMB PAK6 PBX1 PBXIP1 PDE4D PDIA3 PDLIM7 PDS5A PER2 PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PRKN PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM10 RBM38 RCHY1 RESF1 RIDA RLIM RNF10 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS27A RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SORBS2 SRC SREK1 SRSF11 STK11 SUMO1 TAF1 TBP TCAP TERT TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420
Entrez ID		25	4193
HPRD ID		01809	01272
Ensembl ID		ENSG00000097007	ENSG00000135679
Uniprot IDs		A0A024R8E2 P00519 Q59FK4	A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0
PDB IDs		1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 4ZOG 5DC0 5DC4 5DC9 5HU9 5MO4 5NP2 5OAZ 6AMV 6AMW 6BL8 6NPE 6NPU 6NPV 6XR6 6XR7 6XRG	1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6HFA 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O 6SQO 6T2D 6T2E 6T2F 6Y4Q 7AD0 7AI0 7AI1
Enriched GO Terms of Interacting Partners?
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