CADM1 and PSMA6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CADM1	PSMA6
Description		cell adhesion molecule 1	proteasome 20S subunit alpha 6
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Synapse	Proteasome Complex P-body Nucleus Nucleoplasm Cytosol Proteasome Core Complex Polysome Nuclear Matrix Proteasome Core Complex, Alpha-subunit Complex Myofibril Sarcomere Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity	RNA Binding Endopeptidase Activity Protein Binding Purine Ribonucleoside Triphosphate Binding NF-kappaB Binding
	Biological Process	Positive Regulation Of Cytokine Production T Cell Mediated Cytotoxicity Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatogenesis Cell Recognition Cell Differentiation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Activated T Cell Proliferation Detection Of Stimulus	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Adult body size ( 32376654) Anorexia nervosa ( 31308545) Body mass index ( 28552196 31978080 28892062 25673413) Body size at age 10 ( 32376654) Cardiovascular risk factors (age interaction) ( 20838585) Childhood body mass index ( 33045005) Chronotype ( 30696823) Coffee consumption ( 31046077) Cutaneous squamous cell carcinoma ( 27424798 32041948) Diastolic blood pressure ( 34074324) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heel bone mineral density ( 30598549 28869591) Left-handedness ( 32989287) Menarche (age at onset) ( 27182965 25231870) Obesity-related traits ( 23251661) Serum linoleic acid concentration in metabolic syndrome ( 31991592) Systolic blood pressure ( 34074324) Thyroid stimulating hormone levels ( 30367059 32769997) Type 2 diabetes (age of onset) ( 28060188) Waist circumference ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Creatine kinase levels ( 29403010) Psoriasis ( 25903422 20953189)
Interacting Genes		8 interacting genes: ATF7IP CASK DNAJC5 EPB41L3 HYOU1 MPP3 PSMA6 SDCBP	36 interacting genes: ALKBH4 BRCA1 BRME1 C19orf47 CADM1 ECT2 ERH HSPB1 KRTAP4-2 LIG4 LIMD2 NEDD8 PAXIP1 PLK1 POLR2L PSMA2 PSMA3 PSMA4 PSMA7 PSMB5 PSMB6 PSMB8 PSMC6 PSMD3 RNF170 RTP5 SIRPA SMCO3 TEPSIN TRIM39 TSPYL1 UBC USP4 ZBTB44 ZKSCAN4 ZNF596
Entrez ID		23705	5687
HPRD ID		05746	04171
Ensembl ID		ENSG00000182985	ENSG00000100902
Uniprot IDs		A0A4Z1 Q9BY67 X5D7A8 X5D8W0 X5DQR8 X5DQS5	A0A140VK44 P60900
PDB IDs		3BIN 4H5S	4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSG 6MSH 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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