POLA2 and POLA1

Number of citations of the paper that reports this interaction (PubMedID 8223465)
47

Data Source:
HPRD (in vivo, in vitro)

		POLA2	POLA1
Description		DNA polymerase alpha 2, accessory subunit	DNA polymerase alpha 1, catalytic subunit
Image
GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix
	Molecular Function	Molecular_function DNA Binding Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation	DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs		Dacarbazine	Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)	Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2	25 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A SUMO2 TP53 XRCC5
Entrez ID		23649	5422
HPRD ID		10160	02416
Ensembl ID		ENSG00000014138	ENSG00000101868
Uniprot IDs		Q14181	A6NMQ1 P09884
PDB IDs		2KEB 4E2I 4Y97 5EXR	1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7
Enriched GO Terms of Interacting Partners?
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