TSPAN15 and SYNE4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TSPAN15	SYNE4
Description		tetraspanin 15	spectrin repeat containing nuclear envelope family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Nuclear Body Cell Junction Late Endosome Membrane Intracellular Membrane-bounded Organelle Tetraspanin-enriched Microdomain	Integral Component Of Nuclear Outer Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
	Molecular Function	Protein Binding Enzyme Binding	Protein Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Protein Maturation Protein Localization To Plasma Membrane	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (placlitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)
Interacting Genes		14 interacting genes: ADAMDEC1 BTRC CHI3L1 GYPC KLRC3 RGS2 RUFY2 SERBP1 SETDB1 SLC25A16 STRIT1 SYNE4 TCHP TSPO	57 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B WDR62 ZNF250 ZNF648
Entrez ID		23555	163183
HPRD ID		15511	08776
Ensembl ID		ENSG00000099282	ENSG00000181392
Uniprot IDs		O95858	Q8N205
PDB IDs			6R16 6WMD
Enriched GO Terms of Interacting Partners?
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