MAPK8IP2 and DUSP16

Number of citations of the paper that reports this interaction (PubMedID 12524447)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MAPK8IP2	DUSP16
Description		mitogen-activated protein kinase 8 interacting protein 2	dual specificity phosphatase 16
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein-containing Complex Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Signaling Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway	Dephosphorylation Negative Regulation Of MAPK Cascade MAPK Export From Nucleus MAPK Phosphatase Export From Nucleus, Leptomycin B Sensitive
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy Signaling by MAPK mutants
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)
Interacting Genes		85 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	10 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 TRIM54
Entrez ID		23542	80824
HPRD ID		09674	09525
Ensembl ID		ENSG00000008735	ENSG00000111266
Uniprot IDs		Q13387	A0A024RAR2 Q9BY84
PDB IDs			2VSW 3TG3 4YR8
Enriched GO Terms of Interacting Partners?
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