HEY2 and KRTAP6-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HEY2	KRTAP6-1
Description		hes related family bHLH transcription factor with YRPW motif 2	keratin associated protein 6-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex	Cytosol Intermediate Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Negative Regulation Of Transcription By Transcription Factor Localization Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Notch Signaling Involved In Heart Development Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis	Keratinization
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Keratinization
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)
Interacting Genes		28 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HEY1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4	90 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414
Entrez ID		23493	337966
HPRD ID		05243	11218
Ensembl ID		ENSG00000135547	ENSG00000184724
Uniprot IDs		Q5TF93 Q9UBP5	Q3LI64
PDB IDs
Enriched GO Terms of Interacting Partners?
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