SF3B1 and NUDT21

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		SF3B1	NUDT21
Description		splicing factor 3b subunit 1	nudix hydrolase 21
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Centrosome MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Nuclear Body Centriolar Satellite Paraspeckles
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing	MRNA Polyadenylation MRNA Processing Posttranscriptional Regulation Of Gene Expression Cell Differentiation Positive Regulation Of MRNA Cleavage Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Positive Regulation Of MRNA Polyadenylation Messenger Ribonucleoprotein Complex Assembly Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		H3B-8800
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		104 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG GTF3C3 HSPD1 IL7R MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NOP58 NUDT21 PHF5A PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 STRADB SUMO2 TCERG1 TOP1 U2AF2 WBP4	119 interacting genes: A2M ATXN1 CARM1 CDC42 CEP126 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G ESR1 EXOSC6 F13A1 FAM90A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIFAP3 KRT75 MASP1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-2 MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200B MIR205 MIR206 MIR20A MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-2 MIR9-2 MIR92A1 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYL6 NEDD4 NGEF NIF3L1 NTAQ1 POLR2C PSMF1 PSPC1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 S100PBP SEM1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP SNRNP70 SPAG8 SRPK1 TCERG1 TEPSIN TLE1 TRA2A TRIM23 TRIM27 WWOX ZNF655 ZRANB1
Entrez ID		23451	11051
HPRD ID		09281	05400
Ensembl ID		ENSG00000115524	ENSG00000167005
Uniprot IDs		B4DGZ4 O75533	A0A024R6W2 O43809
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q 7ABG 7ABH 7ABI	2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T 5R4P 5R4Q 5R4R 5R4S 5R4T 5R4U 5R64 5R65 5R66 5R67
Enriched GO Terms of Interacting Partners?
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