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SIRT1 and PRMT1
Number of citations of the paper that reports this interaction (PubMedID
28883095
)
10
Data Source:
BioGRID
(enzymatic study)
SIRT1
PRMT1
Description
sirtuin 1
protein arginine methyltransferase 1
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Heterochromatin
Fibrillar Center
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Chromatin Silencing Complex
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
PML Body
RDNA Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Methylosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
NAD+ ADP-ribosyltransferase Activity
Histone Deacetylase Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Nuclear Receptor Binding
NAD-dependent Histone Deacetylase Activity
Deacetylase Activity
Enzyme Binding
Protein Deacetylase Activity
NAD-dependent Protein Deacetylase Activity
Histone Binding
Identical Protein Binding
HLH Domain Binding
BHLH Transcription Factor Binding
Metal Ion Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
Mitogen-activated Protein Kinase Binding
NAD+ Binding
Protein-propionyllysine Depropionylase Activity
Keratin Filament Binding
Promoter-specific Chromatin Binding
RNA Binding
Protein Binding
Methyltransferase Activity
N-methyltransferase Activity
Protein Methyltransferase Activity
Methyl-CpG Binding
Protein-arginine N-methyltransferase Activity
Enzyme Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Mitogen-activated Protein Kinase P38 Binding
S-adenosyl-L-methionine Binding
Biological Process
Single Strand Break Repair
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Synthesis Involved In DNA Repair
Angiogenesis
Ovulation From Ovarian Follicle
Cellular Glucose Homeostasis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Adaptive Immune Response
Chromatin Organization
DNA Methylation-dependent Heterochromatin Assembly
Protein ADP-ribosylation
Protein Deacetylation
Triglyceride Mobilization
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Muscle Organ Development
Cell Aging
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Negative Regulation Of Gene Expression
Regulation Of Centrosome Duplication
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Regulation Of Glucose Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Histone Deacetylation
Peptidyl-lysine Acetylation
Macrophage Differentiation
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Prostaglandin Biosynthetic Process
Heterochromatin Assembly
Protein Destabilization
Negative Regulation Of TOR Signaling
Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Insulin
Circadian Regulation Of Gene Expression
Leptin-mediated Signaling Pathway
Regulation Of Smooth Muscle Cell Apoptotic Process
Peptidyl-lysine Deacetylation
Cellular Triglyceride Homeostasis
Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphorylation
Response To Hydrogen Peroxide
Behavioral Response To Starvation
Cholesterol Homeostasis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Leptin
Positive Regulation Of MHC Class II Biosynthetic Process
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Insulin Receptor Signaling Pathway
White Fat Cell Differentiation
Negative Regulation Of Helicase Activity
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Histone H3-K9 Methylation
Negative Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Histone H3-K9 Modification
Cellular Response To Hydrogen Peroxide
Regulation Of Bile Acid Biosynthetic Process
UV-damage Excision Repair
Histone H3 Deacetylation
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Histone H3-K14 Acetylation
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Protein Depropionylation
Regulation Of Cellular Response To Heat
Negative Regulation Of Histone H3-K9 Trimethylation
Negative Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Adipose Tissue Development
Histone H3-K9 Deacetylation
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Histone H4-K16 Acetylation
Negative Regulation Of Cellular Response To Testosterone Stimulus
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Cellular Senescence
In Utero Embryonic Development
Protein Methylation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
RNA Splicing
Histone Methylation
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Neuron Projection Development
Histone H4-R3 Methylation
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Hemoglobin Biosynthetic Process
Cardiac Muscle Tissue Development
Protein Homooligomerization
Positive Regulation Of P38MAPK Cascade
Pathways
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression
SIRT1 negatively regulates rRNA expression
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
Heme signaling
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Maturation of nucleoprotein
Drugs
Resveratrol
Selisistat
Cambinol
S-adenosyl-L-homocysteine
Diseases
GWAS
Atrial fibrillation (
30061737
)
Chronotype (
30696823
)
Diverticular disease (
30177863
)
Molybdenum levels (
26025379
)
Pulse pressure (
30224653
)
Schizophrenia (
29483656
)
Interacting Genes
65 interacting genes:
AFP
AKT1
AR
ARNTL
BAZ1B
BCL11A
BHLHE41
BRIP1
CDK6
CENATAC
CHFR
CLOCK
CSNK2B
CTTN
E2F1
EP300
ESRRA
EZH2
FOS
FOXM1
FOXO1
FOXO3
GAPDH
H1-5
H3C1
HES1
HEY2
HIC1
HIPK2
HNF4A
HOXB9
MAPK8
MPHOSPH8
MYCN
NBN
NDN
NMNAT1
NR1H2
NR1H3
NR1H4
PARP1
PML
PPARA
PPARG
PPARGC1A
PRMT1
PSME3
RARA
RELA
RICTOR
RRP8
SATB1
SETD7
SMAD7
SMURF2
SNW1
STK11
STK4
SUMO2
TP53
TP73
TRIM28
UBE2I
USP22
VDR
155 interacting genes:
AR
ARPC3
ASH2L
AXIN1
BRCA1
BTG1
BTG2
C4orf17
CAPRIN1
CDC37
CEP162
CIRBP
CNOT8
COIL
DAXX
DCAF16
DCAF8
DHX9
EIF4A1
EP300
ESR1
EWSR1
FAM83D
FAM9A
FBL
FBXL17
FBXO7
FGF2
FLII
FUS
FXR1
GLI1
GPATCH2L
GRHL3
GRIP1
H3C1
H4-16
H4C14
HABP4
HNF4A
HNRNPA1
HNRNPK
HNRNPR
HNRNPU
HNRNPUL1
HROB
IDH3B
IFNAR1
IGSF21
ILF3
IMPDH2
KHDRBS1
KHDRBS2
KHDRBS3
LRIF1
MBD2
MBP
MECOM
MED31
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR138-1
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR34A
MIR34C
MIR363
MIR451A
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MLST8
NCOA1
NCOA2
NCOA3
NOL4
NRIP1
NTAQ1
OFCC1
PDPN
PPARA
PRMT8
QKI
RBM15
RELA
RNF187
RUNX1
S100A8
SAMD3
SHLD1
SIRT1
SPAG8
SPEG
SPSB1
SPSB2
STAT1
STAT5A
STUB1
SUPT5H
TBX6
TERF2
THRB
TP53
TRIM48
UBE4B
VHL
VPS72
WDFY3
WDR33
YLPM1
YWHAG
ZBTB14
ZMYM5
ZNF451
Entrez ID
23411
3276
HPRD ID
08381
04257
Ensembl ID
ENSG00000096717
ENSG00000126457
Uniprot IDs
A0A024QZQ1
A8K128
B0QZ35
E9PC49
Q96EB6
Q99873
PDB IDs
4I5I
4IF6
4IG9
4KXQ
4ZZH
4ZZI
4ZZJ
5BTR
6NT2
Enriched GO Terms of Interacting Partners
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