RPGRIP1L and SLC6A2

		RPGRIP1L	SLC6A2
Description		RPGRIP1 like	solute carrier family 6 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Axonemal Microtubule Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Axoneme Photoreceptor Connecting Cilium Ciliary Rootlet Ciliary Transition Zone Ciliary Basal Body	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Membrane Raft
	Molecular Function	Protein Binding Thromboxane A2 Receptor Binding	Actin Binding Neurotransmitter Transmembrane Transporter Activity Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	In Utero Embryonic Development Establishment Of Planar Polarity Kidney Development Liver Development Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cerebellum Development Lateral Ventricle Development Olfactory Bulb Development Corpus Callosum Development Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Nose Development Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Retinal Rod Cell Development Pericardium Development Cochlea Development Non-motile Cilium Assembly	Neurotransmitter Transport Chemical Synaptic Transmission Response To Xenobiotic Stimulus Monoamine Transport Norepinephrine Transport Sodium Ion Transmembrane Transport Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Neuron Cellular Homeostasis
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)
Drugs			Amphetamine Phentermine Tramadol Guanadrel Reboxetine Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Methylphenidate Meperidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Cyclobenzaprine Maprotiline Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra sinica root Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Metamfetamine Phendimetrazine Nomifensine Amineptine Debrisoquine Bicifadine Milnacipran XEN2174 DDP-225 CRx-119 Amitifadine Mianserin Tesofensine Tapentadol Trodusquemine Desvenlafaxine Dexmethylphenidate Levomilnacipran Vortioxetine Dosulepin Viloxazine Zotepine Dasotraline Netarsudil Solriamfetol
Diseases
GWAS		Abdominal subcutaneous adipose tissue volume ( 34128465) Bipolar disorder ( 21254220) Bipolar disorder or body mass index ( 31754094) Body mass index ( 29273807) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Kidney volume ( 34128465) Plasma anti-thyroglobulin levels ( 29678681) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Visceral adipose tissue volume ( 34128465) Weight ( 28552196)	Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		3 interacting genes: CES1P1 SLC6A2 TBXA2R	3 interacting genes: PPP2R1A RPGRIP1L STX1A
Entrez ID		23322	6530
HPRD ID		17204	01232
Ensembl ID		ENSG00000103494	ENSG00000103546
Uniprot IDs		A0A087WX34 B7ZKJ9 H3BPS4 H3BV03 I3L1B5 Q68CZ1	A0A024R6T9 H3BRE9 P23975
PDB IDs		2YRB
Enriched GO Terms of Interacting Partners?
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