WWC1 and AIFM1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		WWC1	AIFM1
Description		WW and C2 domain containing 1	apoptosis inducing factor mitochondria associated 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Kinase Binding Molecular Adaptor Activity	DNA Binding NADH Dehydrogenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Organ Growth	Response To Ischemia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Toxic Substance Programmed Cell Death Chromosome Condensation Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Protein Import Into Mitochondrial Intermembrane Space Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Cellular Response To Oxygen-glucose Deprivation Response To L-glutamate Regulation Of Apoptotic DNA Fragmentation Cellular Response To Aldosterone
Pathways		Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs			Flavin adenine dinucleotide MCC
Diseases
GWAS		Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)	Bipolar disorder ( 31043756)
Interacting Genes		15 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK WWC2 WWC3	12 interacting genes: CASP3 DCAF7 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP
Entrez ID		23286	9131
HPRD ID		10033	02161
Ensembl ID		ENSG00000113645	ENSG00000156709
Uniprot IDs		Q8IX03	E9PMA0 O95831
PDB IDs		2Z0U 6FB4 6FD0 6FJC 6FJD	1M6I 4BUR 4BV6 4FDC 4LII 5FMH 5FS6 5FS7 5FS8 5FS9 5KVH 5KVI
Enriched GO Terms of Interacting Partners?
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