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SEL1L3 and RBPJ
SEL1L3
RBPJ
Description
SEL1L family member 3
recombination signal binding protein for immunoglobulin kappa J region
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Integral Component Of Membrane
Chromatin
MAML1-RBP-Jkappa- ICN1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Transcription Repressor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Protein N-terminus Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Somitogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Inflammatory Response To Antigenic Stimulus
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Endocardium Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cardiac Left Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Humoral Immune Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Negative Regulation Of Cell Population Proliferation
Auditory Receptor Cell Fate Commitment
Epidermal Cell Fate Specification
Positive Regulation Of Gene Expression
Pituitary Gland Development
B Cell Differentiation
Keratinocyte Differentiation
Negative Regulation Of Ossification
Positive Regulation Of BMP Signaling Pathway
Somatic Stem Cell Population Maintenance
Dorsal Aorta Morphogenesis
Atrioventricular Canal Development
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Timing Of Cell Differentiation
Sebaceous Gland Development
Hair Follicle Maturation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Ventricular Septum Morphogenesis
Club Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Fate Commitment
Notch Signaling Involved In Heart Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Blood Vessel Lumenization
Blood Vessel Endothelial Cell Fate Specification
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of ERBB Signaling Pathway
Positive Regulation Of Ephrin Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS
Systolic blood pressure (
28234671
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Autoimmune traits (pleiotropy) (
30572963
)
Body shape index (
34021172
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Rheumatoid arthritis (
24449572
23143596
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Takayasu arteritis (
33308445
)
Triglyceride levels (
32203549
32154731
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
3 interacting genes:
RBPJ
SLIT2
TUBB3
36 interacting genes:
APP
ART3
CCKAR
CCNF
CIR1
FHL1
GADD45A
GSK3B
HDAC1
HMGB1
HSPB1
INSL3
KAT2A
KAT2B
MAML1
MED27
NCOR1
NCOR2
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PTF1A
RPS6KA6
RSC1A1
SEL1L3
SIN3A
SND1
SNW1
SPEN
SPOP
SPTB
SUFU
TP53
ZCCHC4
ZDHHC7
Entrez ID
23231
3516
HPRD ID
11105
00920
Ensembl ID
ENSG00000091490
ENSG00000168214
Uniprot IDs
A0A024R9V3
Q68CR1
Q06330
PDB IDs
2F8X
3NBN
3V79
6PY8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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