FBXL7 and FBXL18

Number of citations of the paper that reports this interaction (PubMedID 25654763)
17

Data Source:
BioGRID (pull down)

		FBXL7	FBXL18
Description		F-box and leucine rich repeat protein 7	F-box and leucine rich repeat protein 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Centrosome Cytosol SCF Ubiquitin Ligase Complex	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Alzheimer's disease (late onset) ( 26339675) Asthma (corticosteroid response) ( 24486069) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (feminism/equality) ( 22566634) Haemorrhoidal disease ( 33888516) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Response to fenofibrate (total cholesterol levels) ( 27002377) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Visceral fat ( 22589738)	Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) High light scatter reticulocyte count ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Relative hand skill in reading disability ( 24068947)
Interacting Genes		6 interacting genes: APP BIRC5 FBXL18 FCHO1 IMPDH2 TBC1D5	22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		23194	80028
HPRD ID		05740	07753
Ensembl ID		ENSG00000183580	ENSG00000155034
Uniprot IDs		Q9UJT9	A0A024R857 B4DH63 Q96D16
PDB IDs
Enriched GO Terms of Interacting Partners?
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