FLNC and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 11739414)
40

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FLNC	INPPL1
Description		filamin C	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding	Actin Binding Protein Binding SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Actin Cytoskeleton Organization Muscle Cell Development	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Cell-extracellular matrix interactions	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	24 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R DRD2 EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 HYOU1 KMT2A MET SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		2318	3636
HPRD ID		00018	02900
Ensembl ID		ENSG00000128591	ENSG00000165458
Uniprot IDs		Q14315 Q59H94	O15357
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
Enriched GO Terms of Interacting Partners?
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