MYO16 and PPP1CC

Number of citations of the paper that reports this interaction (PubMedID 11588169)
15

Data Source:
HPRD (in vitro)

		MYO16	PPP1CC
Description		myosin XVI	protein phosphatase 1 catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Myosin Complex Perinuclear Region Of Cytoplasm	Protein Phosphatase Type 1 Complex Kinetochore Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Cytoskeletal Motor Activity Protein Binding ATP Binding Protein Phosphatase Binding Actin Filament Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Cerebellum Development Neuron Projection Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 22763476) Chronotype ( 30696823) Colorectal cancer ( 29228715) Dental caries ( 23064961) Eosinophil counts ( 32888494) Ferritin levels ( 33491795) Lung function (FEV1/FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Nose size ( 27182965) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Presence of antiphospholipid antibodies ( 23509613) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Seasonality ( 25562672) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Heart rate ( 23583979)
Interacting Genes		7 interacting genes: CYFIP1 DAOA NCKAP1 NRXN1 PIK3R1 PPP1CA PPP1CC	131 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R32 PPP1R35 PPP1R3A PPP1R3B PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		23026	5501
HPRD ID		14795	08911
Ensembl ID		ENSG00000041515	ENSG00000186298
Uniprot IDs		F8W883 Q9Y6X6	A0A024RBP2 P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28
Enriched GO Terms of Interacting Partners?
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