FOXJ1 and SMURF2

		FOXJ1	SMURF2
Description		forkhead box J1	SMAD specific E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Actin Cytoskeleton Organization Ciliary Basal Body Organization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Cellular Protein Localization Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Activation Of GTPase Activity Positive Regulation Of Lung Ciliated Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways			Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		17 interacting genes: ATP10A CD79B CDK3 FBXO22 FKBP1A GATA6 NMRAL1 OIP5 PECAM1 PRKCA RFX2 RPUSD1 SLC37A3 SMURF2 THRA TRMT6 TWF2	91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FOXJ1 FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SIRT1 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		2302	64750
HPRD ID		03798	06901
Ensembl ID		ENSG00000129654	ENSG00000108854
Uniprot IDs		A0A024R8P1 Q92949	Q96DE7 Q9HAU4
PDB IDs			1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4
Enriched GO Terms of Interacting Partners?
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