SCAP and WDR6

		SCAP	WDR6
Description		SREBF chaperone	WD repeat domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding	RNA Binding Protein Binding Insulin Receptor Substrate Binding
	Biological Process	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading	Cell Cycle Negative Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy TRNA Methylation Regulation Of Cell Cycle
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Refractive error ( 32231278) Triglyceride levels ( 32203549)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Menarche (age at onset) ( 25231870) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: ATG16L1 DHX30 HIPK2 INSIG1 INSIG2 KLHL18 LAMC2 NDUFAF3 PGRMC1 SEC24B SREBF2 WDR6	6 interacting genes: BRCA1 CDC42EP4 G2E3 GRIP1 PTPN3 SCAP
Entrez ID		22937	11180
HPRD ID		03300	06912
Ensembl ID		ENSG00000114650	ENSG00000178252
Uniprot IDs		B7Z6H0 Q12770	A0A087X295 B3KRR8 B4E256 E9PDU5 Q9H9M3 Q9NNW5
PDB IDs		6M49
Enriched GO Terms of Interacting Partners?
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