RALY and SPG7

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RALY	SPG7
Description		RALY heterogeneous nuclear ribonucleoprotein	SPG7 matrix AAA peptidase subunit, paraplegin
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GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Axon Cytoplasm
	Molecular Function	Transcription Coregulator Activity RNA Binding Protein Binding	ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Cholesterol Homeostasis Regulation Of Nucleic Acid-templated Transcription	Proteolysis Nervous System Development Anterograde Axonal Transport Mitochondrial Protein Processing Regulation Of Mitochondrial Membrane Permeability Protein-containing Complex Assembly Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1
Drugs
Diseases
GWAS		Adult body size ( 32376654) Basal cell carcinoma ( 31174203 33549134 27539887) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 22976474) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Facial pigmentation ( 25705849) Hair color ( 29662168) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Melanoma ( 28212542) Nevus count or cutaneous melanoma ( 32341527) Non-melanoma skin cancer ( 29739929) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Skin colour saturation ( 25963972) Skin sensitivity to sun ( 25963972) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell carcinoma ( 26829030) Type 2 diabetes ( 30297969) Vitiligo ( 27723757) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		32 interacting genes: BCCIP BYSL CELF1 EXOC7 GTPBP3 HNRNPC HNRNPCL1 HNRNPD HNRNPH1 HNRNPK HSF2BP KHDRBS1 LNX1 MRPL38 MTUS2 PCBP1 PIK3CD PLOD3 PRKN QKI RALYL RBPMS2 RPL9 SDCBP SKA2 SPG7 THAP1 TIGD3 WDR62 ZBTB24 ZNF408 ZNF76	29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		22913	6687
HPRD ID		11480	04149
Ensembl ID		ENSG00000125970	ENSG00000197912
Uniprot IDs		Q53GL6 Q9UKM9	A0A2R8Y632 Q9UQ90
PDB IDs		1WF1	2QZ4
Enriched GO Terms of Interacting Partners?
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