MRAS and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 15031288)
33

Data Source:
HPRD (in vitro)

		MRAS	RASIP1
Description		muscle RAS oncogene homolog	Ras interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Ras Protein Signal Transduction Multicellular Organism Development Muscle Organ Development Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body shape index ( 34021172) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 24262325 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 19198612 21378990) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 32888494 27863252) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		22808	54922
HPRD ID		06662	15214
Ensembl ID		ENSG00000158186	ENSG00000105538
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	Q5U651 Q7L251 Q8IUR2
PDB IDs			5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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