FGG and VTN

Number of citations of the paper that reports this interaction (PubMedID 11744726)
19

Data Source:
HPRD (in vivo, in vitro)

		FGG	VTN
Description		fibrinogen gamma chain	vitronectin
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Polysaccharide Binding
	Biological Process	Cell-matrix Adhesion Protein Secretion Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein-containing Complex Assembly Platelet Maturation Fibrinolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Negative Regulation Of Platelet Aggregation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways		Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs		Thrombin Human thrombin Thrombin alfa	Abciximab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Fibrinogen levels ( 26561523) Glycine levels ( 30837465) Prothrombin time ( 29403010) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731 33339817) Osteoprotegerin levels ( 25080503)
Interacting Genes		12 interacting genes: APP F13A1 F13B FGA FGB ICAM1 ITGA2B ITGAM ITGB3 SERPINA5 VKORC1 VTN	47 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 DLG2 DLG3 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 SNTG1 TGFB1 TGFB2 TNFRSF11B UBQLN2 VEGFA
Entrez ID		2266	7448
HPRD ID		00621	01902
Ensembl ID		ENSG00000171557	ENSG00000109072
Uniprot IDs		A0A140VJJ6 P02679	D9ZGG2 P04004
PDB IDs		1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
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