FGFR4 and ARNT

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FGFR4	ARNT
Description		fibroblast growth factor receptor 4	aryl hydrocarbon receptor nuclear translocator
Image
GO Annotations	Cellular Component	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle Receptor Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Positive Regulation Of Kinase Activity Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Protein Autophosphorylation Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs		Heparin Ponatinib Lenvatinib Erdafitinib Pemigatinib
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 28552196 25282103 31562340) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 32499647 30718926) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 26785701 25673412)	Blood protein levels ( 28240269) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785 28212542) Metabolic syndrome ( 31589552) Platelet count ( 32888494) Rhegmatogenous retinal detachment ( 23585552) Tea consumption ( 31046077) Urate levels ( 23263486)
Interacting Genes		85 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA2 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IFT80 IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDGFRA PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 STAT1 STAT3 STC2 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1	77 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TP53 TRIP11 TUBB2A UBE2I
Entrez ID		2264	405
HPRD ID		00625	00524
Ensembl ID		ENSG00000160867	ENSG00000143437
Uniprot IDs		B4DVP5 J3KPQ0 P22455	A8K6P0 B0AZM1 P27540 Q53F30
PDB IDs		1QCT 4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8	1D7G 1X0O 2A24 2ARN 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C
Enriched GO Terms of Interacting Partners?
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