FGFR3 and STK32B

		FGFR3	STK32B
Description		fibroblast growth factor receptor 3	serine/threonine kinase 32B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Transport Vesicle Receptor Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Skeletal System Development Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Kinase Activity Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Negative Regulation Of Developmental Growth Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway	Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways		Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer
Drugs		XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
Diseases
GWAS		Bladder cancer ( 24163127 20972438) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)	Age at suicide ( 31476763) Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease progression score ( 29860282) Celiac disease ( 23936387) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Essential tremor ( 27797806) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Vascular endothelial growth factor levels ( 31217265)
Interacting Genes		49 interacting genes: ADD1 ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GMPS GPSM3 GRB2 GRK4 GTF3C1 HBZ HNRNPL IDUA IRF2BPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3 STK32B	1 interacting genes: FGFR3
Entrez ID		2261	55351
HPRD ID		00624	15446
Ensembl ID		ENSG00000068078	ENSG00000152953
Uniprot IDs		P22607 Q0IJ44	B2R9M8 Q9NY57
PDB IDs		1RY7 2LZL 4K33 6LVM 6PNX 7DHL
Enriched GO Terms of Interacting Partners?
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