JAZF1 and NR2C2

Number of citations of the paper that reports this interaction (PubMedID 15302918)
34

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		JAZF1	NR2C2
Description		JAZF zinc finger 1	nuclear receptor subfamily 2 group C member 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex	Chromatin Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways			Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Alcoholic chronic pancreatitis ( 28754779) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Eosinophilic esophagitis ( 29904099) Eye color ( 33692100) Fasting glucose ( 34059833) FEV1 ( 30804560) Free thyroxine concentration ( 24722205) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 19343178 23563607 18952825) Hip circumference adjusted for BMI ( 34021172 25673412) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Prostate cancer ( 18264096 31562322 34012061) Prostate-specific antigen levels ( 28139693) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 26606652 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systolic blood pressure ( 30224653 30578418) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Triglyceride levels ( 32203549) Type 1 diabetes ( 34127860) Type 2 diabetes ( 27189021 22885922 18372903 24509480 30054458 26961502 29358691 30297969 31118516 32499647 20581827 28869590) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)	Alcohol and nicotine co-dependence ( 22488850)
Interacting Genes		4 interacting genes: FAM9B NR2C2 PPARG RXRA	24 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RPL36 RXRB TAB1 TAB2 TRAF2 TRIM55
Entrez ID		221895	7182
HPRD ID		09373	03253
Ensembl ID		ENSG00000153814	ENSG00000177463
Uniprot IDs		Q86VZ6	F2YGU2 P49116
PDB IDs			3P0U
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?