FCGR3A and GP6

Number of citations of the paper that reports this interaction (PubMedID 10961879)
44

Data Source:
HPRD (in vivo)

		FCGR3A	GP6
Description		Fc fragment of IgG receptor IIIa	glycoprotein VI platelet
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Transmembrane Signaling Receptor Activity IgG Binding	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Enzyme Linked Receptor Protein Signaling Pathway Platelet Activation Collagen-activated Signaling Pathway Positive Regulation Of Platelet Aggregation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 28240269) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 20526338 29185836) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Venous thromboembolism ( 31420334)
Interacting Genes		20 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A FCGR2A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		2214	51206
HPRD ID		00903	10406
Ensembl ID		ENSG00000203747	ENSG00000088053
Uniprot IDs		H0Y755 P08637	Q9HCN6
PDB IDs		3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5	2GI7 5OU7 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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