ALDH1B1 and EXOSC10

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		ALDH1B1	EXOSC10
Description		aldehyde dehydrogenase 1 family member B1	exosome component 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding
	Biological Process	Carbohydrate Metabolic Process Ethanol Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Ethanol oxidation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Clostridioides difficle infection in antibiotics-users ( 33841421) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		5 interacting genes: EXOSC10 FABP2 FES OGT XRN2	37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		219	5394
HPRD ID		00005	16180
Ensembl ID		ENSG00000137124	ENSG00000171824
Uniprot IDs		A0A384MTJ7 P30837	Q01780
PDB IDs			2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R
Enriched GO Terms of Interacting Partners?
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