FANCF and FANCL

Number of citations of the paper that reports this interaction (PubMedID 24910428)
52

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, imaging technique)

		FANCF	FANCL
Description		FA complementation group F	FA complementation group L
Image
GO Annotations	Cellular Component	Nucleoplasm Fanconi Anaemia Nuclear Complex	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex
	Molecular Function	Molecular_function Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Biological_process Interstrand Cross-link Repair	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Population Proliferation
Pathways		Fanconi Anemia Pathway	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Generalized epilepsy ( 30531953) HDL cholesterol levels ( 32203549) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: CTBP1 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCG FANCL HES1 ICAM1 MARK3 OLFM2 TCP11	48 interacting genes: ACVR1 ANTKMT BMPR1B C19orf54 CADPS CERCAM CHCHD3 CTBP1 CTDSP1 CYB5R2 DDAH2 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GATA1 GGN GRN HDHD3 HES1 HOXD4 ID2 IHO1 IKZF3 KIFC3 KRTAP11-1 KRTAP13-2 KRTAP19-6 LZTS2 METTL15 MORN3 PCNA RBM45 RIMBP3 RNF11 SCNM1 SNF8 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W UFSP1 YPEL3 ZNF581
Entrez ID		2188	55120
HPRD ID		04589	06997
Ensembl ID		ENSG00000183161	ENSG00000115392
Uniprot IDs		A3KME0 Q9NPI8	Q9NW38
PDB IDs		2IQC	3ZQS 4CCG
Enriched GO Terms of Interacting Partners?
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