FANCC and USP14

Number of citations of the paper that reports this interaction (PubMedID 14499622)
15

Data Source:
BioGRID (two hybrid)

		FANCC	USP14
Description		FA complementation group C	ubiquitin specific peptidase 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Germ Cell Development Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Interstrand Cross-link Repair Brain Morphogenesis Protein-containing Complex Assembly Neuronal Stem Cell Population Maintenance	Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Ub-specific processing proteases
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)
Interacting Genes		54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32	12 interacting genes: ATF2 CXCR4 FANCC OGT SEM1 SPAG5-AS1 TRIM11 UBC USP15 USP21 USP28 XRCC6
Entrez ID		2176	9097
HPRD ID		01967	06279
Ensembl ID		ENSG00000158169	ENSG00000101557
Uniprot IDs		A0A024R9N2 A0A087WW44 B4E3W2 Q00597	P54578
PDB IDs			2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS
Enriched GO Terms of Interacting Partners?
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