EYA1 and GNAZ

Number of citations of the paper that reports this interaction (PubMedID 11950062)
21

Data Source:
HPRD (in vitro, two hybrid)

		EYA1	GNAZ
Description		EYA transcriptional coactivator and phosphatase 1	G protein subunit alpha z
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body Protein-DNA Complex	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Pattern Specification Process Mesodermal Cell Fate Specification Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Anatomical Structure Development Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bell's palsy ( 33602968) Chin dimples ( 27182965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Longevity (85 years and older) ( 24688116) Paneth cell defects in Crohn's disease ( 28352666) Sleep-related phenotypes ( 17903308) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)
Interacting Genes		9 interacting genes: DACH1 GNAI2 GNAZ GSK3B H2AX NDUFB9 SIX1 SIX2 SIX3	16 interacting genes: ADORA1 APP DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7
Entrez ID		2138	2781
HPRD ID		03388	00746
Ensembl ID		ENSG00000104313	ENSG00000128266
Uniprot IDs		A0A024R813 A0A2R8Y6K4 A6NCB9 B3KXR1 F8WB53 Q0P517 Q99502	P19086 Q8IY73
PDB IDs
Enriched GO Terms of Interacting Partners?
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